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Browsing by Author "Golemis E."

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A novel HSP90 inhibitor-drug conjugate to SN38 is highly effective in small cell lung cancer

Gaponova A.; Nikonova A.; Deneka A.; Kopp M.; Kudinov A.; Skobeleva N.; Khazak V.; Ogawa L.; Cai K.; Duncan K.; Duncan J.; Egleston B.; Proia D.; Boumber Y.; Golemis E. (2016)

©2016 AACR.Purpose: Small cell lung cancer (SCLC) is a highly aggressive disease representing 12% to 13% of total lung cancers, with median survival of <2 years. No targeted therapies have proven effective in SCLC. Although ...
Acquisition of estrogen independence induces TOB1-related mechanisms supporting breast cancer cell proliferation

Zhang Y.; Nasto R.; Varghese R.; Jablonski S.; Serebriiskii I.; Surana R.; Calvert V.; Bebu I.; Murray J.; Jin L.; Johnson M.; Riggins R.; Ressom H.; Petricoin E.; Clarke R.; Golemis E.; Weiner L. (2016)

© 2016 Macmillan Publishers Limited.Resistance to therapies targeting the estrogen pathway remains a challenge in the treatment of estrogen receptor-positive breast cancer. To address this challenge, a systems biology ...
An improved method of delivering a sclerosing agent for the treatment of malignant pleural effusion

Beck T.; Deneka A.; Chai L.; Kanach C.; Johal P.; Alvarez N.; Boumber Y.; Golemis E.; Laub G. (2019)

© 2019 The Author(s). Background: Malignant pleural effusion (MPE) is a devastating sequela associated with cancer. Talc pleurodesis is a common treatment strategy for MPE but has been estimated to be unsuccessful in up ...
Anti-Müllerian Hormone Signaling Regulates Epithelial Plasticity and Chemoresistance in Lung Cancer

Beck T.; Korobeynikov V.; Kudinov A.; Georgopoulos R.; Solanki N.; Andrews-Hoke M.; Kistner T.; Pépin D.; Donahoe P.; Nicolas E.; Einarson M.; Zhou Y.; Boumber Y.; Proia D.; Serebriiskii I.; Golemis E. (2016)

© 2016 The Author(s)Anti-Müllerian hormone (AMH) and its type II receptor AMHR2, both previously thought to primarily function in gonadal tissue, were unexpectedly identified as potent regulators of transforming growth ...
Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer

Korobeynikov V.; Borakove M.; Feng Y.; Wuest W.; Koval A.; Nikonova A.; Serebriiskii I.; Chernoff J.; Borges V.; Golemis E.; Shagisultanova E. (2019)

© 2019, The Author(s). Purpose: The serine-threonine kinases Aurora A (AURKA) and p21-activated kinase 1 (PAK1) are frequently overexpressed in breast tumors, with overexpression promoting aggressive breast cancer phenotypes ...
Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization

Ramirez U.; Nikonova A.; Liu H.; Pecherskaya A.; Lawrence S.; Serebriiskii I.; Zhou Y.; Robinson M.; Einarson M.; Golemis E.; Jaffe E. (2015)

© 2015 Ramirez et al. Background: Overexpression or mutation of the epidermal growth factor receptor (EGFR) potently enhances the growth of many solid tumors. Tumor cells frequently display resistance to mechanistically-distinct ...
Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization

Ramirez U.; Nikonova A.; Liu H.; Pecherskaya A.; Lawrence S.; Serebriiskii I.; Zhou Y.; Robinson M.; Einarson M.; Golemis E.; Jaffe E. (2015)

© Ramirez et al. 2015. Background: Overexpression or mutation of the epidermal growth factor receptor (EGFR) potently enhances the growth of many solid tumors. Tumor cells frequently display resistance to mechanistically-distinct ...
Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients

Serebriiskii I.; Connelly C.; Frampton G.; Newberg J.; Cooke M.; Miller V.; Ali S.; Ross J.; Handorf E.; Arora S.; Lieu C.; Golemis E.; Meyer J. (2019)

© 2019, The Author(s). Colorectal cancer (CRC) is increasingly appreciated as a heterogeneous disease, with factors such as microsatellite instability (MSI), cancer subsite within the colon versus rectum, and age of diagnosis ...
Comprehensive genomic landscapes in early and later onset colorectal cancer

Lieu C.; Golemis E.; Serebriiskii I.; Newberg J.; Hemmerich A.; Connelly C.; Messersmith W.; Eng C.; Gail Eckhardt S.; Frampton G.; Cooke M.; Meyer J. (2019)

© 2019 American Association for Cancer Research. Purpose: The incidence rates of colorectal cancers are increasing in young adults. The objective of this study was to investigate genomic differences between tumor samples ...
EGFR and RB1 as dual biomarkers in HPV-negative head and neck cancer

Beck T.; Georgopoulos R.; Shagisultanova E.; Sarcu D.; Handorf E.; Dubyk C.; Lango M.; Ridge J.; Astsaturov I.; Serebriiskii I.; Burtness B.; Mehra R.; Golemis E. (2016)

© 2016 American Association for Cancer Research.Clinical decision making for human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is predominantly guided by disease stage and anatomic location, ...
Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members

Deneka A.; Korobeynikov V.; Golemis E. (2015)

© 2015 Elsevier B.V.. The CAS (Crk-associated substrate) adaptor protein family consists of four members: CASS1/BCAR1/p130Cas, CASS2/NEDD9/HEF1/Cas-L, CASS3/EFS/Sin and CASS4/HEPL. While CAS proteins lack enzymatic activity, ...
Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR

Gabitova L.; Restifo D.; Gorin A.; Manocha K.; Handorf E.; Yang D.; Cai K.; Klein-Szanto A.; Cunningham D.; Kratz L.; Herman G.; Golemis E.; Astsaturov I. (2015)

© 2015 The Authors. Meiosis-activating sterols (MAS) are substrates of SC4MOL and NSDHL in the cholesterol pathway and are important for normal organismal development. Oncogenic transformation by epidermal growth factor ...
Ganetespib limits ciliation and cystogenesis in autosomal-dominant polycystic kidney disease (ADPKD)

Proia D.; Golemis E. (2018)

© 2018 FASEB. Autosomal-dominant polycystic kidney disease (ADPKD) is associated with progressive formation of renal cysts, kidney enlargement, hypertension, and typically end-stage renal disease. In ADPKD, inherited ...
Genetic Variants That Predispose to DNA Double-Strand Breaks in Lymphocytes from a Subset of Patients with Familial Colorectal Carcinomas

Arora S.; Yan H.; Cho I.; Fan H.; Luo B.; Gai X.; Bodian D.; Vockley J.; Zhou Y.; Handorf E.; Egleston B.; Andrake M.; Nicolas E.; Serebriiskii I.; Yen T.; Hall M.; Golemis E.; Enders G. (2015)

© 2015 AGA Institute. Background & Aims DNA structural lesions are prevalent in sporadic colorectal cancer. Therefore, we proposed that gene variants that predispose to DNA double-strand breaks (DSBs) would be found in ...
Identification of evolutionarily conserved DNA damage response genes that alter sensitivity to cisplatin

Gaponova A.; Deneka A.; Beck T.; Liu H.; Andrianov G.; Nikonova A.; Nicolas E.; Einarson M.; Golemis E.; Serebriiskii I. (2017)

Ovarian, head and neck, and other cancers are commonly treated with cisplatin and other DNA damaging cytotoxic agents. Altered DNA damage response (DDR) contributes to resistance of these tumors to chemotherapies, some ...
Interaction of germline variants in a family with a history of early-onset clear cell renal cell carcinoma

Nicolas E.; Demidova E.; Iqbal W.; Serebriiskii I.; Vlasenkova R.; Ghatalia P.; Zhou Y.; Rainey K.; Forman A.; Dunbrack R.; Golemis E.; Hall M.; Daly M.; Arora S. (2019)

© 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc. Background: Identification of genetic factors causing predisposition to renal cell carcinoma has helped improve screening, ...
Mechanisms for nonmitotic activation of Aurora-A at cilia

Korobeynikov V.; Deneka A.; Golemis E. (2017)

© 2017 The Author(s).Overexpression of the Aurora kinase A (AURKA) is oncogenic in many tumors. Many studies of AURKA have focused on activities of this kinase in mitosis, and elucidated the mechanisms by which AURKA ...
Microscopy-Based automated live cell screening for small molecules that affect ciliation

Zhang P.; Kiseleva A.; Korobeynikov V.; Liu H.; Einarson M.; Golemis E. (2019)

© 2019 Zhang, Kiseleva, Korobeynikov, Liu, Einarson and Golemis. The primary monocilium, or cilium, is a single antenna-like organelle that protrudes from the surface of most mammalian cell types, and serves as a signaling ...
Musashi-2 (MSI2) supports TGF-β signaling and inhibits claudins to promote non-small cell lung cancer (NSCLC) metastasis

Kudinov A.; Deneka A.; Nikonova A.; Beck T.; Ahn Y.; Liu X.; Martinez C.; Schultz F.; Reynolds S.; Yang D.; Cai K.; Yaghmour K.; Baker K.; Egleston B.; Nicolas E.; Chikwem A.; Andrianov G.; Singh S.; Borghaei H.; Serebriiskii I.; Gibbons D.; Kurie J.; Golemis E.; Boumber Y. (2016)

© 2016, National Academy of Sciences. All rights reserved.Non-small cell lung cancer (NSCLC) has a 5-y survival rate of ∼16%, with most deaths associated with uncontrolled metastasis. We screened for stem cell identity-related ...
NEDD9 promotes oncogenic signaling, a stem/mesenchymal gene signature, and aggressive ovarian cancer growth in mice

Golemis E.; Connolly D. (2018)

© 2018, Macmillan Publishers Limited, part of Springer Nature. Neural precursor cell expressed, developmentally downregulated 9 (NEDD9) supports oncogenic signaling in a number of solid and hematologic tumors. Little is ...

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Browsing by Author "Golemis E."

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