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Browsing by Author "Genkin D."

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Administration of Myelin Basic Protein Peptides Encapsulated in Mannosylated Liposomes Normalizes Level of Serum TNF- α and IL-2 and Chemoattractants CCL2 and CCL4 in Multiple Sclerosis Patients

Lomakin Y.; Belogurov A.; Glagoleva I.; Stepanov A.; Zakharov K.; Okunola J.; Smirnov I.; Genkin D.; Gabibov A. (2016)

© 2016 Yakov Lomakin et al.We have previously shown that immunodominant MBP peptides encapsulated in mannosylated liposomes (Xemys) effectively suppressed experimental allergic encephalomyelitis (EAE). Within the frames ...
CD206-Targeted Liposomal Myelin Basic Protein Peptides in Patients with Multiple Sclerosis Resistant to First-Line Disease-Modifying Therapies: A First-in-Human, Proof-of-Concept Dose-Escalation Study

Belogurov A.; Zakharov K.; Lomakin Y.; Surkov K.; Avtushenko S.; Kruglyakov P.; Smirnov I.; Makshakov G.; Lockshin C.; Gregoriadis G.; Genkin D.; Gabibov A.; Evdoshenko E. (2016)

© 2016, The Author(s).Previously, we showed that CD206-targeted liposomal delivery of co-encapsulated immunodominant myelin basic protein (MBP) sequences MBP46–62, MBP124–139 and MBP147–170 (Xemys) suppressed experimental ...
CD206-Targeted Liposomal Myelin Basic Protein Peptides in Patients with Multiple Sclerosis Resistant to First-Line Disease-Modifying Therapies: A First-in-Human, Proof-of-Concept Dose-Escalation Study

Belogurov A.; Zakharov K.; Lomakin Y.; Surkov K.; Avtushenko S.; Kruglyakov P.; Smirnov I.; Makshakov G.; Lockshin C.; Gregoriadis G.; Genkin D.; Gabibov A.; Evdoshenko E. (2016)

© 2016 The Author(s)Previously, we showed that CD206-targeted liposomal delivery of co-encapsulated immunodominant myelin basic protein (MBP) sequences MBP46–62, MBP124–139 and MBP147–170 (Xemys) suppressed experimental ...
Chemical polysialylation and in vivo tetramerization improve pharmacokinetic characteristics of recombinant human butyrylcholinesterase-based bioscavengers

Terekhov S.; Smirnov I.; Shamborant O.; Bobik T.; Ilyushin D.; Murashev A.; Dyachenko I.; Palikov V.; Knorre V.; Belogurov A.; Ponomarenko N.; Kuzina E.; Genkin D.; Masson P.; Gabibov A. (2015)

© 2015 Park-media, Ltd. Organophosphate toxins (OPs) are the most toxic low-molecular compounds. The extremely potent toxicity of OPs is determined by their specificity toward the nerve system. Human butyrylcholinesterase ...
Chemical polysialylation of recombinant human proteins

Smirnov I.; Vorobiev I.; Belogurov A.; Genkin D.; Deyev S.; Gabibov A. (2015)

© Springer Science+Business Media New York 2015. All right reserved. Design of drug with prolonged therapeutic action is one of the rapid developing fields of modern medical science and required implementation of different ...
Influence of recombinant histone H1.3 on the efficiency of lentiviral transduction of human cells in vitro

Solovyeva V.; Isaev A.; Genkin D.; Rizvanov A. (2012)

Lentiviral vectors are widely used in genetic modification of human and animal cells (lentiviral transduction) to enhance their therapeutic potential by expression of recombinant protective and trophic factors. Genetic ...

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Browsing by Author "Genkin D."

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