Browsing by Author "Gardini A."

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  • ARID1A spatially partitions interphase chromosomes 
    Wu S.; Fatkhutdinov N.; Rosin L.; Luppino J.; Iwasaki O.; Tanizawa H.; Tang H.; Kossenkov A.; Gardini A.; Noma K.; Speicher D.; Joyce E.; Zhang R. (2019)
    © 2019 by the Authors. ARID1A, a subunit of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex, localizes to both promoters and enhancers to influence transcription. However, the role of ARID1A in ...
  • SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells 
    Wu S.; Fatkhutdinov N.; Fukumoto T.; Bitler B.; Park P.; Kossenkov A.; Trizzino M.; Tang H.; Zhang L.; Gardini A.; Speicher D.; Zhang R. (2018)
    © 2018, The Author(s). Inactivation of the subunits of SWI/SNF complex such as ARID1A is synthetically lethal with inhibition of EZH2 activity. However, mechanisms of de novo resistance to EZH2 inhibitors in cancers with ...

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