Browsing by Author "Gaponova A."

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A novel HSP90 inhibitor-drug conjugate to SN38 is highly effective in small cell lung cancer

Gaponova A.; Nikonova A.; Deneka A.; Kopp M.; Kudinov A.; Skobeleva N.; Khazak V.; Ogawa L.; Cai K.; Duncan K.; Duncan J.; Egleston B.; Proia D.; Boumber Y.; Golemis E. (2016)

©2016 AACR.Purpose: Small cell lung cancer (SCLC) is a highly aggressive disease representing 12% to 13% of total lung cancers, with median survival of <2 years. No targeted therapies have proven effective in SCLC. Although ...
Identification of evolutionarily conserved DNA damage response genes that alter sensitivity to cisplatin

Gaponova A.; Deneka A.; Beck T.; Liu H.; Andrianov G.; Nikonova A.; Nicolas E.; Einarson M.; Golemis E.; Serebriiskii I. (2017)

Ovarian, head and neck, and other cancers are commonly treated with cisplatin and other DNA damaging cytotoxic agents. Altered DNA damage response (DDR) contributes to resistance of these tumors to chemotherapies, some ...
Tumor-targeted SN38 inhibits growth of early stage non-small cell lung cancer (NSCLC) in a KRas/p53 transgenic mouse model

Deneka A.; Haber L.; Kopp M.; Gaponova A.; Nikonova A.; Golemis E. (2017)

© 2017 Deneka et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...

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