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Browsing by Author "Gafurov O."

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Antidromic Spike Propagation and Dissimilar Expression of P2X, 5-HT, and TRPV1 Channels in Peripheral vs. Central Sensory Axons in Meninges

Gafurov O.; Koroleva K.; Giniatullin R. (2021)

Background: The terminal branches of the trigeminal nerve in meninges are supposed to be the origin site of migraine pain. The main function of these peripheral sensory axons is the initiation and propagation of spikes in ...
Double-Binding Botulinum Molecule with Reduced Muscle Paralysis: Evaluation in In Vitro and In Vivo Models of Migraine

Andreou A.P.; Leese C.; Greco R.; Demartini C.; Corrie E.; Simsek D.; Zanaboni A.; Koroleva K.; Lloyd J.O.; Lambru G.; Doran C.; Gafurov O.; Seward E.; Giniatullin R.; Tassorelli C.; Davletov B. (2020)

© 2020, The Author(s). With a prevalence of 15%, migraine is the most common neurological disorder and among the most disabling diseases, taking into account years lived with disability. Current oral medications for migraine ...
Improvement of Nociceptive Spike Clusterization with Shape Approximation

Gafurov O.; Zakharov A.; Koroleva K.; Giniatullin R. (2017)

© 2017, Springer Science+Business Media, LLC. Cluster spike analysis is widely used for studies of neuronal activity when electrical signals are sorted out and grouped according to the different shapes. We recently applied ...
Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine?

Mikhailov N.; Leskinen J.; Fagerlund I.; Poguzhelskaya E.; Giniatullina R.; Gafurov O.; Malm T.; Karjalainen T.; Gröhn O.; Giniatullin R. (2019)

© 2019 Elsevier Ltd Background: Recent discovery of mechanosensitive Piezo receptors in trigeminal ganglia suggested the novel molecular candidate for generation of migraine pain. However, the contribution of Piezo channels ...
Meningeal mast cells contribute to ATP-induced nociceptive firing in trigeminal nerve terminals: Direct and indirect purinergic mechanisms triggering migraine pain

Koroleva K.; Gafurov O.; Guselnikova V.; Nurkhametova D.; Giniatullina R.; Sitdikova G.; Mattila O.; Lindsberg P.; Malm T.; Giniatullin R. (2019)

© 2019 Koroleva, Gafurov, Guselnikova, Nurkhametova, Giniatullina, Sitdikova, Mattila, Lindsberg, Malm and Giniatullin. Peripheral mechanisms of primary headaches such as a migraine remain unclear. Meningeal afferents ...
Modeling a Nociceptive Neuro-Immune Synapse Activated by ATP and 5-HT in Meninges: Novel Clues on Transduction of Chemical Signals Into Persistent or Rhythmic Neuronal Firing

Suleimanova A.; Talanov M.; Gafurov O.; Gafarov F.; Koroleva K.; Virenque A.; Noe F.M.; Mikhailov N.; Nistri A.; Giniatullin R. (2020)

© Copyright © 2020 Suleimanova, Talanov, Gafurov, Gafarov, Koroleva, Virenque, Noe, Mikhailov, Nistri and Giniatullin. Extracellular ATP and serotonin (5-HT) are powerful triggers of nociceptive firing in the meninges, a ...

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Browsing by Author "Gafurov O."

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