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Browsing by Author "Einarson M."

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Anti-Müllerian Hormone Signaling Regulates Epithelial Plasticity and Chemoresistance in Lung Cancer

Beck T.; Korobeynikov V.; Kudinov A.; Georgopoulos R.; Solanki N.; Andrews-Hoke M.; Kistner T.; Pépin D.; Donahoe P.; Nicolas E.; Einarson M.; Zhou Y.; Boumber Y.; Proia D.; Serebriiskii I.; Golemis E. (2016)

© 2016 The Author(s)Anti-Müllerian hormone (AMH) and its type II receptor AMHR2, both previously thought to primarily function in gonadal tissue, were unexpectedly identified as potent regulators of transforming growth ...
Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization

Ramirez U.; Nikonova A.; Liu H.; Pecherskaya A.; Lawrence S.; Serebriiskii I.; Zhou Y.; Robinson M.; Einarson M.; Golemis E.; Jaffe E. (2015)

© 2015 Ramirez et al. Background: Overexpression or mutation of the epidermal growth factor receptor (EGFR) potently enhances the growth of many solid tumors. Tumor cells frequently display resistance to mechanistically-distinct ...
Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization

Ramirez U.; Nikonova A.; Liu H.; Pecherskaya A.; Lawrence S.; Serebriiskii I.; Zhou Y.; Robinson M.; Einarson M.; Golemis E.; Jaffe E. (2015)

© Ramirez et al. 2015. Background: Overexpression or mutation of the epidermal growth factor receptor (EGFR) potently enhances the growth of many solid tumors. Tumor cells frequently display resistance to mechanistically-distinct ...
Identification of evolutionarily conserved DNA damage response genes that alter sensitivity to cisplatin

Gaponova A.; Deneka A.; Beck T.; Liu H.; Andrianov G.; Nikonova A.; Nicolas E.; Einarson M.; Golemis E.; Serebriiskii I. (2017)

Ovarian, head and neck, and other cancers are commonly treated with cisplatin and other DNA damaging cytotoxic agents. Altered DNA damage response (DDR) contributes to resistance of these tumors to chemotherapies, some ...
Microscopy-Based automated live cell screening for small molecules that affect ciliation

Zhang P.; Kiseleva A.; Korobeynikov V.; Liu H.; Einarson M.; Golemis E. (2019)

© 2019 Zhang, Kiseleva, Korobeynikov, Liu, Einarson and Golemis. The primary monocilium, or cilium, is a single antenna-like organelle that protrudes from the surface of most mammalian cell types, and serves as a signaling ...
Synthetic lethal targeting of mitotic checkpoints in HPV-negative head and neck cancer

Deneka A.; Einarson M.; Bennett J.; Nikonova A.; Elmekawy M.; Zhou Y.; Lee J.; Burtness B.; Golemis E. (2020)

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Head and neck squamous cell carcinomas (HNSCC) affect more than 800,000 people annually worldwide, causing over 15,000 deaths in the US. Among HNSCC cancers, human ...
Unexpected activities in regulating ciliation contribute to off-target effects of targeted drugs

Kiseleva A.; Korobeynikov V.; Nikonova A.; Zhang P.; Makhov P.; Deneka A.; Einarson M.; Serebriiskii I.; Liu H.; Peterson J.; Golemis E. (2019)

© 2019 American Association for Cancer Research. Purpose: For many tumors, signaling exchanges between cancer cells and other cells in their microenvironment influence overall tumor signaling. Some of these exchanges depend ...

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Browsing by Author "Einarson M."

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