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Browsing by Author "Cines D."

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Blood clot contraction differentially modulates internal and external fibrinolysis

Tutwiler V.; Peshkova A.; Le Minh G.; Zaitsev S.; Litvinov R.; Cines D.; Weisel J. (2019)

© 2018 International Society on Thrombosis and Haemostasis Essentials Clot contraction influences the rate of fibrinolysis in vitro. Internal fibrinolysis is enhanced ∼2-fold in contracted vs. uncontracted blood clots. ...
Kinetics and mechanics of clot contraction are governed by the molecular and cellular composition of the blood

Tutwiler V.; Litvinov R.; Lozhkin A.; Peshkova A.; Lebedeva T.; Ataullakhanov F.; Spiller K.; Cines D.; Weisel J. (2016)

© 2016 by The American Society of Hematology. Platelet-driven blood clot contraction (retraction) is thought to promote wound closure and secure hemostasis while preventing vascular occlusion. Notwithstanding its importance, ...
Neutrophil a-defensins promote thrombosis in vivo by altering fibrin formation, structure, and stability

Abu-Fanne R.; Stepanova V.; Litvinov R.; Abdeen S.; Bdeir K.; Higazi M.; Maraga E.; Nagaswami C.; Mukhitov A.; Weisel J.; Cines D.; Higazi A. (2019)

© 2019 by The American Society of Hematology. Inflammation and thrombosis are integrated, mutually reinforcing processes, but the interregulatory mechanisms are incompletely defined. Here, we examined the contribution of ...
Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia

Tutwiler V.; Madeeva D.; Ahn H.; Andrianova I.; Hayes V.; Zheng X.; Cines D.; McKenzie S.; Poncz M.; Rauova L. (2016)

© 2016 by The American Society of Hematology. Heparin-induced thrombocytopenia (HIT) is characterized by a high incidence of thrombosis, unlike other antibody-mediated causes of thrombocytopenia. We have shown that monocytes ...

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Browsing by Author "Cines D."

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