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Browsing by Author "Chelyshev Y."

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Adenoviral vector carrying glial cell-derived neurotrophic factor for direct gene therapy in comparison with human umbilical cord blood cell-mediated therapy of spinal cord injury in rat

Mukhamedshina Y.; Shaymardanova G.; Garanina; Salafutdinov I.; Rizvanov; Islamov R.; Chelyshev Y. (2015)

© 2015 International Spinal Cord Society Study design:Experimental study.Objective:To evaluate the treatment of spinal cord injury with glial cell-derived neurotrophic factor (GDNF) delivered using an adenoviral vector ...
Adenoviral vector carrying glial cell-derived neurotrophic factor for direct gene therapy in comparison with human umbilical cord blood cell-mediated therapy of spinal cord injury in rat

Mukhamedshina Y.; Shaymardanova G.; Garanina; Salafutdinov I.; Rizvanov; Islamov R.; Chelyshev Y. (2016)

© 2016 International Spinal Cord Society.Study design:Experimental study.Objective:To evaluate the treatment of spinal cord injury with glial cell-derived neurotrophic factor (GDNF) delivered using an adenoviral vector ...
Assessment of glial scar, tissue sparing, behavioral recovery and axonal regeneration following acute transplantation of genetically modified human umbilical cord blood cells in a rat model of spinal cord contusion

Mukhamedshina Y.; Garanina E.; Masgutova G.; Galieva L.; Sanatova E.; Chelyshev Y.; Rizvanov A. (2016)

©2016 Mukhamedshina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
Atherosclerotic plaque and hydroxyapatite nanostructures studied by high-frequency EPR

Gafurov M.; Yavkin B.; Biktagirov T.; Mamin G.; Orlinskii S.; Izotov V.; Salakhov M.; Klimashina E.; Putlayev V.; Abdul'yanov V.; Ignatjev I.; Khairullin R.; Zamochkin A.; Chelyshev Y. (2013)

A series of nanosized (20 nm and larger) samples of hydroxyapatite powders synthesized by wet preparation method and doped with Mn2+ and Pb2+ ions were studied by 94 GHz pulsed electron paramagnetic resonance (EPR). The ...
Characterization of spinal cord glial cells in a model of hindlimb unloading in mice

Chelyshev Y.; Muhamedshina Y.; Povysheva T.; Shaymardanova G.; Rizvanov A.; Nigmetzyanova M.; Tiapkina O.; Bondarenko N.; Nikolskiy E.; Islamov R. (2014)

© 2014 IBRO. Exposure to microgravity has been shown to result in damaging alterations to skeletal muscle, bones, and inner organs. In this study, we investigated the effects of microgravity by using a hindlimb unloading ...
Connection Between the Carotid Plaque Instability and Paramagnetic Properties of the Intrinsic Mn<sup>2+</sup> Ions

Gafurov M.; Chelyshev Y.; Ignatyev I.; Zanochkin A.; Mamin G.; Iskhakova K.; Kiiamov A.; Murzakhanov F.; Orlinskii S. (2016)

© 2016, Springer Science+Business Media New York.The pulsed W-band (the microwave frequency of 94 GHz, magnetic field of 3.4 T) electron paramagnetic resonance (EPR) comparative studies of a series of 20 atherosclerotic ...
Cu(II) content in the structures of the peripheral nervous system at their damage

Aganov A.; Guseva D.; Zverev D.; Silkin N.; Shtyrlin V.; Chelyshev Y. (2006)

Employing electron paramagnetic resonance with diethyldithiocarbamate as a spin trap it was shown that after the transection of the rat sciatic nerve the Cu(II) content increased in the proximal stump and did not change ...
Delivery of cord blood cells modified with adenoviral vectors expressing GDNF into the area of spinal cord injury stimulates recovery of motor function and supports a population of glial cells

Mukhamedshina Y.; Shaymardanova G.; Salafutdinov I.; Rizvanov A.; Povysheva T.; Masgutova G.; Nigmetzyanova M.; Chelyshev Y. (2013)

On the model of rat spinal cord dosed contusion at Th8 level studied the effect of delivery into the area of damage of glialcell- line-derived neurotrophic factor gene using adenovirustransduced of human umbilical cord ...
Effects of transplantation of human cord blood mononuclear cells expressing the recombinant VEGF and FGF2 genes into spinal cord traumatic injury sites in rats

Shaimardanova G.; Mukhamedshina Y.; Rizvanov A.; Salafutdinov I.; Chelyshev Y. (2013)

A model of dosed TVIII spinal cord contusion trauma in rats was used to study the effects of immediate single-dose transplantation of human cord blood mononuclear cells transformed with the recombinant genes for neurotrophic ...
Electrophysiological, morphological, and ultrastructural features of the injured spinal cord tissue after transplantation of human umbilical cord blood mononuclear cells genetically modified with the VEGF and GDNF genes

Mukhamedshina Y.; Gilazieva Z.; Arkhipova S.; Galieva L.; Garanina E.; Shulman A.; Yafarova G.; Chelyshev Y.; Shamsutdinova N.; Rizvanov A. (2017)

© 2017 Y. O. Mukhamedshina et al.In this study, we examined the efficacy of human umbilical cord blood mononuclear cells (hUCB-MCs), genetically modified with the VEGF and GDNF genes using adenoviral vectors, on posttraumatic ...
Epidural stimulation combined with triple gene therapy for spinal cord injury treatment

Islamov R.; Bashirov F.; Fadeev F.; Shevchenko R.; Izmailov A.; Markosyan V.; Sokolov M.; Kuznetsov M.; Davleeva M.; Garifulin R.; Salafutdinov I.; Nurullin L.; Chelyshev Y.; Lavrov I. (2020)

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The translation of new therapies for spinal cord injury to clinical trials can be facilitated with large animal models close in morpho-physiological scale to humans. ...
Evaluation of direct and cell-mediated triple-gene therapy in spinal cord injury in rats

Islamov R.; Izmailov A.; Sokolov M.; Fadeev P.; Bashirov F.; Eremeev A.; Shaymardanova G.; Shmarov M.; Naroditskiy B.; Chelyshev Y.; Lavrov I.; Palotás A. (2017)

© 2017 Elsevier Inc.Current treatment options for spinal cord injury (SCI) are scarce. One of the most promising innovative approaches include gene-therapy, however no single gene has so far been shown to be of clinical ...
Investigation of atherosclerotic plaque by high-frequency EPR

Biktagirov T.; Chelyshev Y.; Gafurov M.; Mamin G.; Orlinskii S.; Osin Y.; Salakhov M. (2013)

We present a comparative study of samples of aorta walls from male patients with atherosclerosis and hydroxyapatite powders with the average size of crystallites of 30 nm synthesized by the wet precipitation technique by ...
Mesenchymal stem cells and the neuronal microenvironment in the area of spinal cord injury

Mukhamedshina Y.; Gracheva O.; Mukhutdinova D.; Chelyshev Y.; Rizvanov A. (2019)

© 2019 Medknow Publications. All rights reserved. Cell-based technologies are used as a therapeutic strategy in spinal cord injury (SCI). Mesenchymal stem cells (MSCs), which secrete various neurotrophic factors and ...
Myelinated fibers of the mouse spinal cord after a 30-day space flight

Povysheva T.; Rezvyakov P.; Shaimardanova G.; Nikolskii E.; Islamov R.; Chelyshev Y.; Grygoryev A. (2016)

© 2016, Pleiades Publishing, Ltd.Myelinated fibers and myelin-forming cells in the spinal cord at the L3–L5 level were studied in C57BL/6N mice that had spent 30 days in space. Signs of destruction of myelin in different ...
Neuroprotective action of new pyrimidine derivatives on rat spinal cord injury

Povysheva T.; Semenov V.; Galyametdinova I.; Reznik V.; Knni K.; Kolesnikov P.; Kuznetsova S.; Chelyshev Y. (2016)

Effects of the systemic administration of xymedon and its derivatives-L-ascorbate and para-aminobenzoate 1,2-dihydro-4,6-dimethyl-l-(2-hydroxyethyl) pyrimid-2-one (compounds 29D and 34D, respectively) - have been studied ...
Paramagnetic Manganese in the Atherosclerotic Plaque of Carotid Arteries

Chelyshev Y.; Gafurov M.; Ignatyev I.; Zanochkin A.; Mamin G.; Sorokin B.; Sorokina A.; Lyapkalo N.; Gizatullina N.; Mukhamedshina Y.; Orlinskii S. (2016)

© 2016 Yury Chelyshev et al.The search for adequate markers of atherosclerotic plaque (AP) instability in the context of assessment of the ischemic stroke risk in patients with atherosclerosis of the carotid arteries as ...
Poly(ε-Caprolactone) nerve conduit and local delivery of vegf and fgf2 genes stimulate neuroregeneration

Nikolaev S.; Gallyamov A.; Mamin G.; Chelyshev Y. (2014)

We studied regeneration of rat sciatic nerve while overcoming of a 5-mm diastasis with the aid of nanostructured conduit made of biocompatible and biodegradable poly(ε-caprolactone) and filled with fibrin hydrogel matrix. ...
Post-traumatic changes in the spinal cord in rats after transplantation of mononuclear cells from human umbilical blood modified with the vegf and fgf2 genes

Shaimardanova G.; Mukhamedshina Y.; Arkhipova S.; Salafutdinov I.; Rizvanov A.; Chelyshev Y. (2012)

Experiments were carried out using 25 white laboratory rats. A model of dosed contusional trauma to the spinal cord at the TVIII level in rats was used to measure the areas of pathological cavities and the numbers of ...
Post-Traumatic Changes in the Spinal Cord in Rats after Transplantation of Mononuclear Cells from Human Umbilical Blood Modified with the vegf and fgf2 Genes

Shaimardanova G.; Mukhamedshina Y.; Arkhipova S.; Salafutdinov I.; Rizvanov A.; Chelyshev Y. (2012)

Experiments were carried out using 25 white laboratory rats. A model of dosed contusional trauma to the spinal cord at the T VIII level in rats was used to measure the areas of pathological cavities and the numbers of ...

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Browsing by Author "Chelyshev Y."

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