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A segmentation approach for mammographic images and its clinical value

Неизвестный автор (2018)

© 2017 IEEE. We developed the nested contour algorithm (NCA) - a segmentation method for X-ray mammography images and tested it on a set of 1532 images of 356 women with morphologically proven breast cancer of various ...
Anti-leprosy drug clofazimine inhibits growth of triple-negative breast cancer cells via inhibition of canonical Wnt signaling

Koval A.; Vlasov P.; Shichkova P.; Khunderyakova S.; Markov Y.; Panchenko J.; Volodina A.; Kondrashov F.; Katanaev V. (2014)

Research on existing drugs often discovers novel mechanisms of their action and leads to the expansion of their therapeutic scope and subsequent remarketing. The Wnt signaling pathway is of the immediate therapeutic ...
Binase Do Not Change Level of Intracellular RNA in Breast Cancer Cells

Pukhovskaya V.; Sokolova E.; Zelenikhin P. (2017)

© 2017, Springer Science+Business Media, LLC. We analyzed changes of intracellular RNA level in breast cancer cells using BT-20, BT-474, and MCF-7 cell lines. It is the continuation of our former studying the effect of ...
Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer

Korobeynikov V.; Borakove M.; Feng Y.; Wuest W.; Koval A.; Nikonova A.; Serebriiskii I.; Chernoff J.; Borges V.; Golemis E.; Shagisultanova E. (2019)

© 2019, The Author(s). Purpose: The serine-threonine kinases Aurora A (AURKA) and p21-activated kinase 1 (PAK1) are frequently overexpressed in breast tumors, with overexpression promoting aggressive breast cancer phenotypes ...
Early Diagnosis of Breast Cancer: Public Health and Mammographic Screening

Неизвестный автор (2018)

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Malignant breast tumors are the leading oncological pathology (after skin cancer) in the female population all over the world (more than 20%). According ...
Eribulin-trastuzumab combination in HER2-positive metastatic breast cancer: updated results from a Russian observational study

Kovalenko E.I.; Artamonova E.V.; Bolotina L.V.; Zhiliaeva L.A.; Ponomarenko D.M.; Karabina E.V.; Mukhametshina G.Z.; Khasanova A.I.; Ratner E.Y.; Safarova A.R.; Manikhas A.G.; Popova N.O.; Evstigneeva I.V.; Vladimirova L.Y.; Kramskaya L.V.; Karandeeva T.V.; Suslova I.R.; Romanchuk O.V.; Shikina V.E.; Povyshev A.Y.; Osipov M.A.; Cherniakova E.M.; Dergunov A.S.; Volkonskiy M.V.; Chernov I.S.; Shumskaya I.E.; Fael M.M.; Garifullina V.I.; Gudkova I.E. (2021)

Introduction. The standard of 1st line treatment of HER2+ metastatic breast cancer (mBC) is double blockade with trastuzumab and pertuzumab + taxane, 2nd line – Trastuzumab-emtazine. There are no standards for further ...
Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis

Casimiro M.; Di Sante G.; Crosariol M.; Loro E.; Dampier W.; Ertel A.; Yu Z.; Saria E.; Papanikolaou A.; Li Z.; Wang C.; Addya S.; Lisanti M.; Fortina P.; Cardiff R.; Tozeren A.; Knudsen E.; Arnold A.; Pestell R. (2015)

Cyclin D1 is an important molecular driver of human breast cancer but better understanding of its oncogenic mechanisms is needed, especially to enhance efforts in targeted therapeutics. Currently, pharmaceutical initiatives ...
Methods of assessment in mammography: BI-RADS lexicon

Gamirov R.; Rodionov V.; Gamirova R. (2020)

© 2020, Advanced Scientific Research. All rights reserved. The article presents a review of researches in Russia connected with the use of BI-RADS lexicon. The Breast Imaging Reporting and Data System (BI-RADS lexicon) is ...
Obvious and Hidden Reasons of Breast Cancer Cell Sensitivity to Antitumor RNase

Zelenikhin P.; Pukhovskaya V.; Garipov A.; Makeeva A.; Sokolova E.; Ilinskaya O. (2016)

© 2016, Springer Science+Business Media New York.Breast cancer is the second most common cancer in women, but chemotherapy and targeting antibodies possess certain side effects. Today’s efforts are aimed to search of new ...
Polymorphisms in DNA repair genes and breast cancer risk in Russian population: a case–control study

Shadrina A.; Ermolenko N.; Boyarskikh U.; Sinkina T.; Lazarev A.; Petrova V.; Filipenko M. (2016)

© 2014, Springer-Verlag Italia. Genetic variation in DNA repair genes can alter an individual’s capacity to repair damaged DNA and influence the risk of cancer. We tested seven polymorphisms in DNA repair genes XRCC1, ...
Prediction of breast cancer metastasis risk using circulating tumor markers: A follow-up study

Cetintas S.; Tezcan G.; Tunca B.; Egeli U.; Gokgoz M.; Cecener G. (2019)

© 2019 ABMSFBIH. Distant organ tumor dissemination is a major cause of breast cancer-related deaths. In 2010, we analyzed the prognostic importance of the circulating tumor markers (CTMs) cytokeratin 19 (CK19), CK20, ...
RNA interference screening methods to identify proliferation determinants and mechanisms of resistance to immune attack

Zhang Y.; Nasto R.; Jablonski S.; Serebriiskii I.; Surana R.; Murray J.; Johnson M.; Riggins R.; Clarke R.; Golemis E.; Weiner L. (2019)

© 2019 Elsevier Inc. We have used RNA interference (RNAi) screening technology to reveal unknown components of biological signaling pathways including survival mechanisms of estrogen-independent breast cancer cell growth ...
TERT polymorphisms rs2853669 and rs7726159 influence on prostate cancer risk in Russian population

Shadrina A.; Boyarskikh U.; Oskina N.; Sinkina T.; Lazarev A.; Petrova V.; Filipenko M. (2015)

© 2014, International Society of Oncology and BioMarkers (ISOBM). Telomere length and telomerase activity have been hypothesized to play a role in cancer development. The aim of our study was to investigate the association ...
The attitude of women in Russia to the prevention of breast cancer and ovarian cancer: Results of a sociological survey.

Ishkineeva F.; Ozerova K.; Kaveeva A. (2016)

Breast cancer and ovarian cancer are among the most common causes of death for women in Russia. It has been found that women with BRCA1 and BRCA2 gene mutations are at high risk of developing breast cancer and ovarian ...
The Clinical Case of Successful Application of Photodynamic Therapy in the Skin Metastases Treatment of Breast Cancer

Shanazarov N.; Zinchenko S.; Zhapparov E.; Muratov N.; Turzhanova D.; Bilyalov A.; Tashpulatov T. (2021)

The article describes the experience of using photodynamic therapy in the treatment of skin metastases of a patient with breast cancer. The authors note the high effectiveness of this method of treatment in combination ...
The ethnic-specific spectrum of germline nucleotide variants in DNA damage response and repair genes in hereditary breast and ovarian cancer patients of Tatar descent

Brovkina O.; Shigapova L.; Chudakova D.; Gordiev M.; Enikeev R.; Druzhkov M.; Khodyrev D.; Shagimardanova E.; Nikitin A.; Gusev O. (2018)

© 2018 Frontiers Media S.A. All Rights Reserved. The Russian population consists of more than 100 ethnic groups, presenting a unique opportunity for the identification of hereditary pathogenic mutations. To gain insight ...
The frequency and spectrum of PIK3CA mutations in patients with estrogen receptor-positive HER2-negative advanced breast cancer residing in various regions of Russia

Sokolova T.N.; Aleksakhina S.N.; Yanus G.A.; Sultanbaev A.V.; Menshikov K.V.; Lysenko A.N.; Zukov R.A.; Zyuzyukina A.V.; Murunova Y.N.; Rossokha E.I.; Bakharev S.Y.; Basova E.A.; Kasmynina T.A.; Shumskaya I.S.; Bakshun Y.I.; Musaeva K.S.; Khasanova A.I.; Dmitriev V.N.; Bolieva M.B.; Gadzaova C.H.; Petrenko O.L.; Maksimov D.A.; Vladimirov V.I.; Goldberg V.E.; Popova N.O.; Kibisheva M.V.; Khamgokov Z.M.; Vasilyev A.E.; Iyevleva A.G.; Imyanitov E.N. (2021)

Relevance. PIK3CA belongs to the top three most frequently mutated genes in breast cancer (BC), especially in estrogen receptor (ER) positive, HER2 negative BC subtype. With an approval of selective PI3K-alpha inhibitor, ...
The frequency and spectrum of PIK3CA mutations in patients with estrogen receptor-positive HER2-negative advanced breast cancer residing in various regions of Russia

Sokolova T.N.; Aleksakhina S.N.; Yanus G.A.; Sultanbaev A.V.; Menshikov K.V.; Lysenko A.N.; Zukov R.A.; Zyuzyukina A.V.; Murunova Y.N.; Rossokha E.I.; Bakharev S.Y.; Basova E.A.; Kasmynina T.A.; Shumskaya I.S.; Bakshun Y.I.; Musaeva K.S.; Khasanova A.I.; Dmitriev V.N.; Bolieva M.B.; Gadzaova C.H.; Petrenko O.L.; Maksimov D.A.; Vladimirov V.I.; Goldberg V.E.; Popova N.O.; Kibisheva M.V.; Khamgokov Z.M.; Vasilyev A.E.; Iyevleva A.G.; Imyanitov E.N. (2021)

Relevance. PIK3CA belongs to the top three most frequently mutated genes in breast cancer (BC), especially in estrogen recep-tor (ER) positive, HER2 negative BC subtype. With an approval of selective PI3K-alpha inhibitor, ...

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