Browsing by Author "Boisvert W.A."

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AT<inf>2</inf>R stimulation with C21 prevents arterial stiffening and endothelial dysfunction in the abdominal aorta from mice fed a high-fat diet

González-Blázquez R.; Alcalá M.; Cárdenas-Rebollo J.M.; Viana M.; Steckelings U.M.; Boisvert W.A.; Unger T.; Fernández-Alfonso M.S.; Somoza B.; Gil-Ortega M. (2021)

The aim of the present study was to evaluate the effect of Compound 21 (C21), a selective AT2R agonist, on the prevention of endothelial dysfunction, extracellular matrix (ECM) remodeling and arterial stiffness associated ...
C21 preserves endothelial function in the thoracic aorta from DIO mice: Role for AT<inf>2</inf>, Mas and B<inf>2</inf> receptors

González-Blázquez R.; Alcalá M.; Fernández-Alfonso M.S.; Steckelings U.M.; Paz Lorenzo M.; Viana M.; Boisvert W.A.; Unger T.; Gil-Ortega M.; Somoza B. (2021)

Compound 21 (C21), a selective agonist of angiotensin II type 2 receptor (AT2R), induces vasodilation through NO release. Since AT2R seems to be overexpressed in obesity, we hypothesize that C21 prevents the development ...

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