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Browsing by Author "Bobik T."

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A novel expression cassette delivers efficient production of exclusively tetrameric human butyrylcholinesterase with improved pharmacokinetics for protection against organophosphate poisoning

Terekhov S.; Smirnov I.; Bobik T.; Shamborant O.; Zenkova M.; Chernolovskaya E.; Gladkikh D.; Murashev A.; Dyachenko I.; Palikov V.; Palikova Y.; Knorre V.; Belogurov A.; Ponomarenko N.; Blackburn G.; Masson P.; Gabibov A. (2015)

© 2015 Published by Elsevier B.V. Butyrylcholinesterase is a stoichiometric bioscavenger against poisoning by organophosphorus pesticides and nerve agents. The low level of expression and extremely rapid clearance of ...
Analysis of Immunogenicity of Intracellular CTAR Fragments of Epstein—Barr Virus Latent Phase Protein LMP1

Lomakin Y.; Shmidt A.; Bobik T.; Chernov A.; Pyrkov A.; Aleksandrova N.; Okunola D.; Vaskina M.; Ponomarenko N.; Telegin G.; Dubina M.; Belogurov A. (2017)

© 2017, Springer Science+Business Media, LLC. Intracellular fragments of latent phase protein LMP1 of Epstein—Barr virus, denoted as CTAR1/2/3, can trigger a variety of cell cascades and contribute to the transforming ...
Chemical polysialylation and in vivo tetramerization improve pharmacokinetic characteristics of recombinant human butyrylcholinesterase-based bioscavengers

Terekhov S.; Smirnov I.; Shamborant O.; Bobik T.; Ilyushin D.; Murashev A.; Dyachenko I.; Palikov V.; Knorre V.; Belogurov A.; Ponomarenko N.; Kuzina E.; Genkin D.; Masson P.; Gabibov A. (2015)

© 2015 Park-media, Ltd. Organophosphate toxins (OPs) are the most toxic low-molecular compounds. The extremely potent toxicity of OPs is determined by their specificity toward the nerve system. Human butyrylcholinesterase ...
Expression of DNA-Encoded Antidote to Organophosphorus Toxins in the Methylotrophic Yeast Pichia Pastoris

Terekhov S.; Bobik T.; Mokrushina Y.; Stepanova A.; Aleksandrova N.; Smirnov I.; Belogurov A.; Ponomarenko N.; Gabibov A. (2016)

© 2016, Pleiades Publishing, Inc.A platform for the cloning and expression of active human butyrylcholinesterase (BuChE) in the yeast Pichia рastoris is first presented. Genetic constructs for BuChE gene expression, ...
Microfluidic droplet platform for ultrahigh-throughput single-cell screening of biodiversity

Terekhov S.; Smirnov I.; Stepanova A.; Bobik T.; Mokrushina Y.; Ponomarenko N.; Belogurov A.; Rubtsova M.; Kartseva O.; Gomzikova M.; Moskovtsev A.; Bukatin A.; Dubina M.; Kostryukova E.; Babenko V.; Vakhitova M.; Manolov A.; Malakhova M.; Kornienko M.; Tyakht A.; Vanyushkina A.; Ilina E.; Masson P.; Gabibov A.; Altman S. (2017)

© 2017, National Academy of Sciences. All rights reserved.Ultrahigh-throughput screening (uHTS) techniques can identify unique functionality from millions of variants. To mimic the natural selection mechanisms that occur ...
QM/MM description of newly selected catalytic bioscavengers against organophosphorus compounds revealed reactivation stimulus mediated by histidine residue in the acyl-binding loop

Zlobin A.; Mokrushina Y.; Terekhov S.; Zalevsky A.; Bobik T.; Stepanova A.; Aliseychik M.; Kartseva O.; Panteleev S.; Golovin A.; Belogurov A.; Gabibov A.; Smirnov I. (2018)

© 2018 Zlobin, Mokrushina, Terekhov, Zalevsky, Bobik, Stepanova, Aliseychik, Kartseva, Panteleev, Golovin, Belogurov, Gabibov and Smirnov. Butyrylcholinesterase (BChE) is considered as an efficient stoichiometric antidote ...

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Browsing by Author "Bobik T."

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