Browsing by Author "Bellusci S."

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  • A comprehensive analysis of fibroblast growth factor receptor 2b signaling on epithelial tip progenitor cells during early mouse lung branching morphogenesis 
    Jones M.; Dilai S.; Lingampally A.; Chao C.; Danopoulos S.; Carraro G.; Mukhametshina R.; Wilhelm J.; Baumgart-Vogt E.; Al Alam D.; Chen C.; Minoo P.; Zhang J.; Bellusci S. (2019)
    © 2007 - 2019 Frontiers Media S.A. All Rights Reserved. This study demonstrates that FGF10/FGFR2b signaling on distal epithelial progenitor cells, via ß-catenin/EP300, controls, through a comprehensive set of developmental ...
  • A critical role for miR-142 in alveolar epithelial lineage formation in mouse lung development 
    Shrestha A.; Carraro G.; Nottet N.; Vazquez-Armendariz A.; Herold S.; Cordero J.; Singh I.; Wilhelm J.; Barreto G.; Morty R.; El Agha E.; Mari B.; Chen C.; Zhang J.; Chao C.; Bellusci S. (2019)
    © 2019, Springer Nature Switzerland AG. The respiratory epithelium arises from alveolar epithelial progenitors which differentiate into alveolar epithelial type 1 (AT1) and type 2 (AT2) cells. AT2 cells are stem cells in ...
  • CCL27: Novel cytokine with potential role in pathogenesis of multiple sclerosis 
    Khaiboullina S.; Gumerova A.; Khafizova I.; Martynova E.; Lombardi V.; Bellusci S.; Rizvanov A. (2015)
    © 2015 Svetlana F. Khaiboullina et al. Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease of unknown etiology. Leukocyte infiltration of brain tissue and the subsequent inflammation, demyelination, ...
  • Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development 
    Al Alam D.; El Agha E.; Sakurai R.; Kheirollahi V.; Moiseenko A.; Danopoulos S.; Shrestha A.; Schmoldt C.; Quantius J.; Herold S.; Chao C.; Tiozzo C.; De Langhe S.; Plikus M.; Thornton M.; Grubbs B.; Minoo P.; Rehan V.; Bellusci S. (2015)
    © 2015. Published by The Company of Biologists Ltd. Lipid-containing alveolar interstitial fibroblasts (lipofibroblasts) are increasingly recognized as an important component of the epithelial stem cell niche in the rodent ...
  • Ex vivo analysis of the contribution of FGF10<sup>+</sup> cells to airway smooth muscle cell formation during early lung development 
    El Agha E.; Kheirollahi V.; Moiseenko A.; Seeger W.; Bellusci S. (2017)
    © 2017 Wiley Periodicals, Inc.Background: Airway smooth muscle cells (ASMCs) have been widely studied during embryonic lung development. These cells have been shown to control epithelial bifurcation during branching ...
  • FGF10 promotes regional foetal cardiomyocyte proliferation and adult cardiomyocyte cell-cycle re-entry 
    Rochais F.; Sturny R.; Chao C.; Mesbah K.; Bennett M.; Mohun T.; Bellusci S.; Kelly R. (2014)
    © The Author 2014. Aims Cardiomyocyte proliferation gradually declines during embryogenesis resulting in severely limited regenerative capacities in the adult heart. Understanding the developmental processes controlling ...
  • Fibroblast growth factor 10 alters the balance between goblet and Paneth cells in the adult mouse small intestine 
    Al Alam D.; Danopoulos S.; Schall K.; Sala F.; Almohazey D.; Fernandez G.; Georgia S.; Frey M.; Ford H.; Grikscheit T.; Bellusci S. (2015)
    © 2015 the American Physiological Society. Intestinal epithelial cell renewal relies on the right balance of epithelial cell migration, proliferation, differentiation, and apoptosis. Intestinal epithelial cells consist of ...
  • Generation and validation of MIR-142 knock out mice 
    Shrestha A.; Carraro G.; El Agha E.; Mukhametshina R.; Chao C.; Rizvanov A.; Barreto G.; Bellusci S.; Kalinichenko V. (2015)
    © 2015 Shrestha et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
  • High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX 
    Singh I.; Ozturk N.; Cordero J.; Mehta A.; Hasan D.; Cosentino C.; Sebastian C.; Krüger M.; Looso M.; Carraro G.; Bellusci S.; Seeger W.; Braun T.; Mostoslavsky R.; Barreto G. (2015)
    © 2015 IBCB, SIBS, CAS. All rights reserved. The eukaryotic genome is organized into chromatins, the physiological template for DNA-dependent processes including replication, recombination, repair, and transcription. ...
  • Hmga2 is required for canonical WNT signaling during lung development 
    Singh I.; Mehta A.; Contreras A.; Boettger T.; Carraro G.; Wheeler M.; Cabrera-Fuentes H.; Bellusci S.; Seeger W.; Braun T.; Barreto G. (2014)
    Background: The high-mobility-group (HMG) proteins are the most abundant non-histone chromatin-associated proteins. HMG proteins are present at high levels in various undifferentiated tissues during embryonic development ...
  • Impact of Fgf10 deficiency on pulmonary vasculature formation in a mouse model of bronchopulmonary dysplasia 
    Chao C.; Moiseenko A.; Kosanovic D.; Rivetti S.; El Agha E.; Wilhelm J.; Kampschulte M.; Yahya F.; Ehrhardt H.; Zimmer K.; Barreto G.; Rizvanov A.; Schermuly R.; Reiss I.; Morty R.; Rottier R.; Bellusci S.; Zhang J. (2019)
    © 2018 The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. Bronchopulmonary dysplasia (BPD), characterized by alveoli simplification ...
  • Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis 
    Rubio K.; Singh I.; Dobersch S.; Sarvari P.; Günther S.; Cordero J.; Mehta A.; Wujak L.; Cabrera-Fuentes H.; Chao C.; Braubach P.; Bellusci S.; Seeger W.; Günther A.; Preissner K.; Wygrecka M.; Savai R.; Papy-Garcia D.; Dobreva G.; Heikenwalder M.; Savai-Pullamsetti S.; Braun T.; Barreto G. (2019)
    © 2019, The Author(s). Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and highly lethal lung disease with unknown etiology and poor prognosis. IPF patients die within 2 years after diagnosis mostly due to ...
  • Increased FGF1-FGFRc expression in idiopathic pulmonary fibrosis 
    MacKenzie B.; Korfei M.; Henneke I.; Sibinska Z.; Tian X.; Hezel S.; Dilai S.; Wasnick R.; Schneider B.; Wilhelm J.; El Agha E.; Klepetko W.; Seeger W.; Schermuly R.; Günther A.; Bellusci S. (2015)
    © MacKenzie et al. 2015. Recent clinical studies show that tyrosine kinase inhibitors slow the rate of lung function decline and decrease the number of acute exacerbations in patients with Idiopathic Pulmonary Fibrosis ...
  • Increased FGF1-FGFRc expression in idiopathic pulmonary fibrosis 
    MacKenzie B.; Korfei M.; Henneke I.; Sibinska Z.; Tian X.; Hezel S.; Dilai S.; Wasnick R.; Schneider B.; Wilhelm J.; El Agha E.; Klepetko W.; Seeger W.; Schermuly R.; Günther A.; Bellusci S. (2015)
    © 2015 MacKenzie et al. Background: Recent clinical studies show that tyrosine kinase inhibitors slow the rate of lung function decline and decrease the number of acute exacerbations in patients with Idiopathic Pulmonary ...
  • Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development 
    Luo Y.; El Agha E.; Turcatel G.; Chen H.; Chiu J.; Warburton D.; Bellusci S.; Qian B.; Menke D.; Shi W. (2015)
    © 2015 Luo et al. Background: Adenomatous polyposis coli (Apc) is a tumor suppressor that inhibits Wnt/Ctnnb1. Mutations of Apc will not only lead to familial adenomatous polyposis with associated epithelial lesions, but ...
  • Mesodermal ALK5 controls lung myofibroblast versus lipofibroblast cell fate 
    Li A.; Ma S.; Smith S.; Lee M.; Fischer A.; Borok Z.; Bellusci S.; Li C.; Minoo P. (2016)
    © 2016 Li et al.Background: Epithelial-mesenchymal cross talk is centerpiece in the development of many branched organs, including the lungs. The embryonic lung mesoderm provides instructional information not only for lung ...
  • MicroRNA-142 is a multifaceted regulator in organogenesis, homeostasis, and disease 
    Shrestha A.; Mukhametshina R.; Taghizadeh S.; Vásquez-Pacheco E.; Cabrera-Fuentes H.; Rizvanov A.; Mari B.; Carraro G.; Bellusci S. (2017)
    © 2016 Wiley Periodicals, Inc.Over the past decade, microRNA-142 (miR-142) is emerging as a major regulator of cell fate decision in the hematopoietic system. However, miR-142 is expressed in many other tissues, and recent ...
  • Non-invasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate 
    Mehta A.; Cordero J.; Dobersch S.; Romero-Olmedo A.; Savai R.; Bodner J.; Chao C.; Fink L.; Guzmán-Díaz E.; Singh I.; Dobreva G.; Rapp U.; Günther S.; Ilinskaya O.; Bellusci S.; Dammann R.; Braun T.; Seeger W.; Gattenlöhner S.; Tresch A.; Günther A.; Barreto G. (2016)
    © 2016 The Authors. Published under the terms of the CC BY 4.0 licenseLung cancer (LC) is the leading cause of cancer-related deaths worldwide. Early LC diagnosis is crucial to reduce the high case fatality rate of this ...
  • Origin and characterization of alpha smooth muscle actin-positive cells during murine lung development 
    Moiseenko A.; Kheirollahi V.; Chao C.; Ahmadvand N.; Quantius J.; Wilhelm J.; Herold S.; Ahlbrecht K.; Morty R.; Rizvanov A.; Minoo P.; El Agha E.; Bellusci S. (2017)
    © 2017 The Authors Stem Cells published by Wiley Periodicals, Inc. on behalf of AlphaMed PressACTA2 expression identifies pulmonary airway and vascular smooth muscle cells (SMCs) as well as alveolar myofibroblasts (MYF). ...
  • Quantitative proteome analysis of alveolar type-II cells reveals a connection of integrin receptor subunits beta 2/6 and WNT signaling 
    Mukhametshina R.; Ruhs A.; Singh I.; Hasan D.; Contreras A.; Mehta A.; Nikam V.; Ahlbrecht K.; Carraro G.; Cabrera-Fuentes H.; Jiang D.; Voswinckel R.; Seeger W.; Bellusci S.; Scharffetter-Kochanek K.; Bagaeva T.; Preissner K.; Boettger T.; Braun T.; Krüger M.; Barreto G. (2013)
    Alveolar type-II cells (ATII cells) are lung progenitor cells responsible for regeneration of alveolar epithelium during homeostatic turnover and in response to injury. Characterization of ATII cells will have a profound ...

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