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Просмотр по автору "Barsegov V."

Просмотр по автору "Barsegov V."

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  • Atomic Structural Models of Fibrin Oligomers 
    Zhmurov A.; Protopopova A.; Litvinov R.; Zhukov P.; Weisel J.; Barsegov V. (2018)
    © 2018 Elsevier Ltd The space-filling fibrin network is a major part of clots and thrombi formed in blood. Fibrin polymerization starts when fibrinogen, a plasma protein, is proteolytically converted to fibrin, which ...
  • Conformational Flexibility and Self-Association of Fibrinogen in Concentrated Solutions 
    Zuev Y.; Litvinov R.; Sitnitsky A.; Idiyatullin B.; Bakirova D.; Galanakis D.; Zhmurov A.; Barsegov V.; Weisel J. (2017)
    © 2017 American Chemical Society. We studied the hydrodynamic behavior of fibrinogen, a blood plasma protein involved in blood clotting, in a broad 0.3-60 mg/mL range of concentration and 5-42 °C temperature using pulsed-field ...
  • Mechanistic Basis for the Binding of RGD- and AGDV-Peptides to the Platelet Integrin αIIbβ3 
    Kononova O.; Litvinov R.; Blokhin D.; Klochkov V.; Weisel J.; Bennett J.; Barsegov V. (2017)
    © 2017 American Chemical Society.Binding of soluble fibrinogen to the activated conformation of the integrin αIIbβ3 is required for platelet aggregation and is mediated exclusively by the C-terminal AGDV-containing ...
  • Molecular packing structure of fibrin fibers resolved by X-ray scattering and molecular modeling 
    Jansen K.A.; Zhmurov A.; Vos B.E.; Portale G.; Hermida-Merino D.; Litvinov R.I.; Tutwiler V.; Kurniawan N.A.; Bras W.; Weisel J.W.; Barsegov V.; Koenderink G.H. (2020)
    © The Royal Society of Chemistry. Fibrin is the major extracellular component of blood clots and a proteinaceous hydrogel used as a versatile biomaterial. Fibrin forms branched networks built of laterally associated ...
  • Regulatory element in fibrin triggers tension-activated transition from catch to slip bonds 
    Litvinov R.; Kononova O.; Zhmurov A.; Marx K.; Barsegov V.; Thirumalai D.; Weisel J. (2018)
    © 2018 National Academy of Sciences. All Rights Reserved. Fibrin formation and mechanical stability are essential in thrombosis and hemostasis. To reveal how mechanical load impacts fibrin, we carried out optical trap-based ...
  • Strength and deformability of fibrin clots: Biomechanics, thermodynamics, and mechanisms of rupture 
    Tutwiler V.; Maksudov F.; Litvinov R.I.; Weisel J.W.; Barsegov V. (2021)
    Fibrin is the major determinant of the mechanical stability and integrity of blood clots and thrombi. To explore the rupture of blood clots, emulating thrombus breakage, we stretched fibrin gels with single-edge cracks of ...
  • Structural Basis of Interfacial Flexibility in Fibrin Oligomers 
    Zhmurov A.; Protopopova A.; Litvinov R.; Zhukov P.; Mukhitov A.; Weisel J.; Barsegov V. (2016)
    © 2016 Elsevier LtdFibrin is a filamentous network made in blood to stem bleeding; it forms when fibrinogen is converted into fibrin monomers that self-associate into oligomers and then to polymers. To gather structural ...

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