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Browsing by Author "Arora S."

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Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients

Serebriiskii I.; Connelly C.; Frampton G.; Newberg J.; Cooke M.; Miller V.; Ali S.; Ross J.; Handorf E.; Arora S.; Lieu C.; Golemis E.; Meyer J. (2019)

© 2019, The Author(s). Colorectal cancer (CRC) is increasingly appreciated as a heterogeneous disease, with factors such as microsatellite instability (MSI), cancer subsite within the colon versus rectum, and age of diagnosis ...
Existing and Emerging Biomarkers for Immune Checkpoint Immunotherapy in Solid Tumors

Arora S.; Velichinskii R.; Lesh R.; Ali U.; Kubiak M.; Bansal P.; Borghaei H.; Edelman M.; Boumber Y. (2019)

© 2019, The Author(s). In the last few years, immunotherapy has transformed the way we treat solid tumors, including melanoma, lung, head neck, breast, renal, and bladder cancers. Durable responses and long-term survival ...
Genetic Variants That Predispose to DNA Double-Strand Breaks in Lymphocytes from a Subset of Patients with Familial Colorectal Carcinomas

Arora S.; Yan H.; Cho I.; Fan H.; Luo B.; Gai X.; Bodian D.; Vockley J.; Zhou Y.; Handorf E.; Egleston B.; Andrake M.; Nicolas E.; Serebriiskii I.; Yen T.; Hall M.; Golemis E.; Enders G. (2015)

© 2015 AGA Institute. Background & Aims DNA structural lesions are prevalent in sporadic colorectal cancer. Therefore, we proposed that gene variants that predispose to DNA double-strand breaks (DSBs) would be found in ...
Interaction of germline variants in a family with a history of early-onset clear cell renal cell carcinoma

Nicolas E.; Demidova E.; Iqbal W.; Serebriiskii I.; Vlasenkova R.; Ghatalia P.; Zhou Y.; Rainey K.; Forman A.; Dunbrack R.; Golemis E.; Hall M.; Daly M.; Arora S. (2019)

© 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc. Background: Identification of genetic factors causing predisposition to renal cell carcinoma has helped improve screening, ...
Prevalence of pathogenic variants in DNA damage response and repair genes in patients undergoing cancer risk assessment and reporting a personal history of early-onset renal cancer

Hartman T.R.; Demidova E.V.; Lesh R.W.; Hoang L.; Richardson M.; Forman A.; Kessler L.; Speare V.; Golemis E.A.; Hall M.J.; Daly M.B.; Arora S. (2020)

© 2020, The Author(s). Pathogenic variants (PVs) in multiple genes are known to increase the risk of early-onset renal cancer (eoRC). However, many eoRC patients lack PVs in RC-specific genes; thus, their genetic risk ...
RRM2B Is Frequently Amplified Across Multiple Tumor Types: Implications for DNA Repair, Cellular Survival, and Cancer Therapy

Iqbal W.; Demidova E.V.; Serrao S.; ValizadehAslani T.; Rosen G.; Arora S. (2021)

RRM2B plays a crucial role in DNA replication, repair and oxidative stress. While germline RRM2B mutations have been implicated in mitochondrial disorders, its relevance to cancer has not been established. Here, using TCGA ...
Systematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancer

Nicolas E.; Arora S.; Zhou Y.; Serebriiskii I.; Andrake M.; Handorf E.; Bodian D.; Vockley J.; Dunbrack R.; Ross E.; Egleston B.; Hall M.; Golemis E.; Giri V.; Daly M. (2015)

Risk assessment for prostate cancer is challenging due to its genetic heterogeneity. In this study, our goal was to develop an operational framework to select and evaluate gene variants that may contribute to familial ...

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Browsing by Author "Arora S."

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