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6-methyluracil derivatives as bifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease

Semenov V.; Zueva I.; Mukhamedyarov M.; Lushchekina S.; Kharlamova A.; Petukhova E.; Mikhailov A.; Podyachev S.; Saifina L.; Petrov K.; Minnekhanova O.; Zobov V.; Nikolsky E.; Masson P.; Reznik V. (2015)

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Novel 6-methyluracil derivatives with ω-(substituted benzylethylamino)alkyl chains at the nitrogen atoms of the pyrimidine ring were designed and synthesized. The numbers ...
Alzheimer's β-amyloid-induced depolarization of skeletal muscle fibers: Implications for motor dysfunctions in dementia

Mukhamedyarov M.; Grishin S.; Yusupova E.; Zefirov A.; Palotás A. (2009)

Numerous findings obtained over the last decades suggest that accumulation of β-amyloid peptide (βAP) plays the central role in the pathogenesis of Alzheimer's disease. It is well established that βAP has wide range of ...
Bacterial enzymes effectively digest Alzheimer's β-amyloid peptide

Danilova Y.; Shagimardanova E.; Margulis A.; Toymentseva A.; Balaban N.; Rudakova N.; Rizvanov A.; Sharipova M.; Palotás A. (2014)

© 2014 Elsevier Inc. Aggregated β-amyloid peptides play key roles in the development of Alzheimer's disease, and recent evidence suggests that microbial particles, among others, can facilitate their polymerization. Bacterial ...
Cellular and receptor mechanisms of impairment of myocardium and aorta contractility at Alzheimer's disease model

Leushina A.; Gaifullina R.; Zefirov A.; Palotas A.; Mukhamedyarov M. (2012)

Introduction: Recent studies certify the existence of link between Alzheimer's disease and cardiovascular pathology, however the mechanisms of this phenomenon is unclear. Here we studied the influence of Alzheimer's β-amyloid ...
Coronary artery bypass surgery provokes alzheimer's disease-like changes in the cerebrospinal fluid

Palotás A.; Reis H.; Bogáts G.; Babik B.; Racsmány M.; Engvau L.; Kecskeméti E.; Juhász A.; Vieira L.; Teixeira A.; Mukhamedyarov M.; Rizvanov A.; Yalvaç M.; Guimarêes M.; Ferreira C.; Zefirov A.; Kiyasov A.; Wang L.; Janka Z.; Kálmán J. (2010)

Several biomarkers are used in confirming the diagnosis of cognitive disorders. This study evaluates whether the level of these markers after heart surgery correlates with the development of cognitive dysfunction, which ...
Disease-specific expression of the serotonin-receptor 5-HT2C in natural killer cells in Alzheimer's dementia

Martins L.; Rocha N.; Torres K.; dos Santos R.; França G.; de Moraes E.; Mukhamedyarov M.; Zefirov A.; Rizvanov A.; Kiyasov A.; Vieira L.; Guimarães M.; Yalvaç M.; Teixeira A.; Bicalho M.; Janka Z.; Romano-Silva M.; Palotás A.; Reis H. (2012)

Alzheimer's dementia (AD) is a degenerative brain disorder characterized mainly by cholinergic failure, but other neuro-transmitters are also deficient especially at late stages of the disease. Misfolded β-amyloid peptide ...
Effects of Transplanted Umbilical Cord Blood Mononuclear Cells Overexpressing GDNF on Spatial Memory and Hippocampal Synaptic Proteins in a Mouse Model of Alzheimer's Disease

Petukhova E.; Mukhamedshina Y.; Salafutdinov I.; Garanina E.; Kaligin M.; Leushina A.; Rizvanov A.; Reis H.; Palotás A.; Zefirov A.; Mukhamedyarov M. (2019)

© 2019 - IOS Press and the authors. All rights reserved. Background/Objective: Alzheimer's disease (AD) is a progressive incurable neurodegenerative disorder. Glial cell line-derived neurotrophic factor (GDNF) is a prominent ...
Inhibition of amyloid formation of amyloid β (1–42), amylin and insulin by 1,5-diazacyclooctanes, a spermine-acrolein conjugate

Kunitomi R.; Pradipta A.R.; Kawabe H.; Lobsiger N.; Tanaka K.; Zako T. (2021)

Amyloid aggregates of proteins are known to be involved in various diseases such as Alzheimer's disease (AD). It is therefore speculated that the inhibition of amyloid formation can play an important role in the prevention ...
New evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's disease

Zueva I.; Dias J.; Lushchekina S.; Semenov V.; Mukhamedyarov M.; Pashirova T.; Babaev V.; Nachon F.; Petrova N.; Nurullin L.; Zakharova L.; Ilyin V.; Masson P.; Petrov K. (2019)

© 2019 Elsevier Ltd Profound synaptic dysfunction contributes to early loss of short-term memory in Alzheimer's disease. This study was set up to analyze possible neuroprotective effects of two dual binding site inhibitors ...
Nutritional modulation of the intestinal microbiota: future opportunities for the prevention and treatment of neuroimmune and neuroinflammatory disease

Lombardi V.; De Meirleir K.; Subramanian K.; Nourani S.; Dagda R.; Delaney S.; Palotás A. (2018)

© 2018 Elsevier Inc. The gut-brain-axis refers to the bidirectional communication between the enteric nervous system and the central nervous system. Mounting evidence supports the premise that the intestinal microbiota ...
Peripheral blood mono-nuclear cells derived from Alzheimer's disease patients show elevated baseline levels of secreted cytokines but resist stimulation with β-amyloid peptide

Rocha N.; Teixeira A.; Coelho F.; Caramelli P.; Guimarães H.; Barbosa I.; da Silva T.; Mukhamedyarov M.; Zefirov A.; Rizvanov A.; Kiyasov A.; Vieira L.; Janka Z.; Palotás A.; Reis H. (2012)

Objectives: Among several other factors, the neuro-toxic β-amyloid peptide (βAP)-induced inflammatory mechanisms have also been implicated in the pathogenesis of Alzheimer's dementia (AD). Cytokines have recently emerged ...
Pharmacological exploration of traditional plants for the treatment of neurodegenerative disorders

Wahid M.; Ali A.; Saqib F.; Aleem A.; Bibi S.; Afzal K.; Baig A.; Khan S.A.; Bin Asad M.H.H. (2020)

© 2020 John Wiley & Sons, Ltd. Alzheimer's disease (AD) is clinically characterized as memory deficits, altered behavior and impaired cognitive functions. The most important risk factor for AD is aging and mounting. ...
Solution structures of Alzheimer's amyloid Aβ13-23 peptide: NMR studies in solution and in SDS

Usachev K.; Filippov A.; Filippova E.; Antzutkin O.; Klochkov V. (2013)

To be believed that interaction of amyloid peptides with the cellular membrane is one of the mechanisms for the neurotoxicity of Aβ. Therefore, structural studies of beta-amyloid in solution and in a "peptide- bio-membrane" ...
Stable Co-Cultivation of the Moss Physcomitrella patens with Human Cells in vitro as a New Approach to Support Metabolism of Diseased Alzheimer Cells

Zakirova E.; Chastukhina I.; Valeeva L.; Vorobev V.; Rizvanov A.; Palotás A.; Shakirov E. (2019)

© 2019 - IOS Press and the authors. All rights reserved. Alzheimer's disease (AD) is a devastating slowly progressive neurodegenerative disorder with no cure. While there are many hypotheses, the exact mechanism causing ...
The mechanism of β-amyloid peptide influence on the retrograde axon transport

Mukhamedyarov M.; Safiullov Z.; Utyasheva R.; Rizvanov A.; Zefirov A.; Islamov R. (2012)

Impairment of axon transport is widespread and early event in a number of neurodegenerative diseases. The goal of study is to investigate the mechanisms of retrograde axon transport impairment in mouse spinal motoneurons ...
Transcriptional Analysis of Blood Lymphocytes and Skin Fibroblasts, Keratinocytes, and Endothelial Cells as a Potential Biomarker for Alzheimer's Disease

Mukhamedyarov M.; Rizvanov A.; Yakupov E.; Zefirov A.; Kiyasov A.; Reis H.; Teixeira A.; Vieira L.; Lima L.; Salafutdinov I.; Petukhova E.; Khaiboullina S.; Schlauch K.; Lombardi V.; Palotás A. (2016)

© 2016 - IOS Press and the authors. All rights reserved.Alzheimer's disease (AD) is a devastating and progressive form of dementia that is typically associated with a build-up of amyloid-β plaques and hyperphosphorylated ...
Use of a combination of the RDC method and NOESY NMR spectroscopy to determine the structure of Alzheimer's amyloid Aβ10-35 peptide in solution and in SDS micelles

Usachev K.; Filippov A.; Antzutkin O.; Klochkov V. (2013)

The spatial structure of Alzheimer's amyloid Aβ10-35- NH2 peptide in aqueous solution at pH 7.3 and in SDS micelles was investigated by use of a combination of the residual dipolar coupling method and two-dimensional NMR ...

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