Kazan state Federal University E-Archive :: Browsing by Author "Ilinskaya O."

Bacterial ribonuclease: Mutagenic effect in microbial test-systems

Ilinskaya O.; Ivanchenko O.; Karamova N. (1995)

Pure enzyme samples of ribonuclease from Bacillus intermedius 7P (known commercially as 'binase') were investigated for genotoxicity in four microbial tests: the Ames plate incorporation method, Ara(R)-assay; the prophage ...

Bacteriophages of soil bacilli: A new multivalent phage of Bacillus altitudinis

Shah Mahmud R.; Garifulina K.; Ulyanova V.; Evtugyn V.; Mindubaeva L.; Khazieva L.; Dudkina E.; Vershinina V.; Kolpakov A.; Ilinskaya O. (2017)

© 2017, Allerton Press, Inc. Bacillus are soil saprophytes, facultative anaerobes developing in the temperature range of 28–37°С. 16S rRNA cataloging shows that these bacteria form a coherent class with broad variability ...

Balnase, a New Dimer-Forming Ribonuclease from Bacillus altitudinis

Dudkina E.; Ulyanova V.; Ilinskaya O. (2017)

© 2016, Springer Science+Business Media New York.Current cancer treatments still remain ineffective and cause side effects which ruinously affect healthy cells. Among new promising anticancer drugs, special attention is ...

Barnase and binase: Twins with distinct fates

Ulyanova V.; Vershinina V.; Ilinskaya O. (2011)

RNases are enzymes that cleave RNAs, resulting in remarkably diverse biological consequences. Many RNases are cytotoxic. In some cases, they attack selectively malignant cells triggering an apoptotic response. A number of ...

Binase and other microbial RNases as potential anticancer agents

Makarov A.; Kolchinsky A.; Ilinskaya O. (2008)

Some RNases possess preferential cytotoxicity against malignant cells. The best known of these RNases, onconase, was isolated from frog oocytes; and is in clinical trials as anticancer therapy. Here we propose an alternative ...

Binase cleaves cellular noncoding RNAs and affects coding mRNAs

Mitkevich V.; Tchurikov N.; Zelenikhin P.; Petrushanko I.; Makarov A.; Ilinskaya O. (2010)

Bacterial RNases are promising tools for the development of anticancer drugs. Neoplastic transformation leads to enhanced accumulation of rRNA and tRNA, and altered expression of regulatory noncoding RNAs. Cleavage of RNA ...

Binase Immobilized on halloysite nanotubes exerts enhanced cytotoxicity toward human colon adenocarcinoma cells

Khodzhaeva V.; Makeeva A.; Ulyanova V.; Zelenikhin P.; Evtugyn V.; Hardt M.; Rozhina E.; Lvov Y.; Fakhrullin R.; Ilinskaya O. (2017)

© 2017 Khodzhaeva, Makeeva, Ulyanova. Many ribonucleases (RNases) are considered as promising tools for antitumor therapy because of their selective cytotoxicity toward cancer cells. Binase, the RNase from Bacillus pumilus, ...

Binase induces apoptosis of transformed myeloid cells and does not induce T-cell immune response

Ilinskaya O.; Zelenikhin P.; Petrushanko I.; Mitkevich V.; Prassolov V.; Makarov A. (2007)

Microbial RNases along with such animal RNases as onconase and BS-RNase are a promising basis for developing new antitumor drugs. We have shown that the Bacillus intermedius RNase (binase) induces selective apoptosis of ...

Binase penetration into alveolar epithelial cells does not induce cell death

Cabrera-Fuentes H.; Kalacheva N.; Mukhametshina R.; Zelenikhin P.; Kolpakov A.; Barreto G.; Preissner K.; Ilinskaya O. (2012)

Microbial ribonucleases possess a broad spectrum of biological activities, which demonstrate stimulating properties at low concentrations and cytotoxicity and genotoxicity at high concentrations. Mechanisms of their ...

Binase penetration into alveolar epithelial cells does not induce cell death

Cabrera Fuentes H.; Katacheva N.; Mukhametshina R.; Zelenikhin P.; Kolpakov A.; Barreto G.; Preissner K.; Ilinskaya O. (2012)

Microbial ribonucleases possess a broad spectra of biological activities, demonstrating stimulating properties at low concentrations and cytotoxicity and genotoxicity at high concentrations. The mechanisms of their penetration ...

Binase-like guanyl-preferring ribonucleases are new members of Bacillus PhoP regulon

Ulyanova V.; Vershinina V.; Ilinskaya O.; Harwood C. (2015)

Copyright © 2014 Elsevier GmbH. All rights reserved. Extracellular low-molecular weight guanyl-preferring ribonucleases (LMW RNases) of Bacillus sp. comprise a group of hydrolytic enzymes that share highly similar structural ...

Binase-like guanyl-preferring ribonucleases are new members of Bacillus PhoP regulon

Ulyanova V.; Vershinina V.; Ilinskaya O.; Harwood C. (2015)

© 2014 Elsevier GmbH. Extracellular low-molecular weight guanyl-preferring ribonucleases (LMW RNases) of Bacillus sp. comprise a group of hydrolytic enzymes that share highly similar structural and catalytic characteristics ...

Biomimetic cell-mediated three-dimensional assembly of halloysite nanotubes

Konnova S.; Sharipova I.; Demina T.; Osin Y.; Yarullina D.; Ilinskaya O.; Lvov Y.; Fakhrullin R. (2013)

Biomimetic architectural assembly of clay nanotube shells on yeast cells was demonstrated producing viable artificial hybrid inorganic-cellular structures (armoured cells). These modified cells were preserved for one ...

Cell targets of antitumor ribonucleases

Mitkevich V.; Makarov A.; Ilinskaya O. (2014)

Several ribonucleases (RNases) are known to exert a toxic effect on tumor cells, but the mechanism of their antitumor activity is still poorly understood. The review considers the RNase-cell component interaction that leads ...

Changing the net charge from negative to positive makes ribonuclease Sa cytotoxic

Ilinskaya O.; Dreyer F.; Mitkevich V.; Shaw K.; Nick Pace C.; Makarov A. (2002)

Ribonuclease Sa (pI = 3.5) from Streptomyces aureofaciens and its 3K (D1K, D17K, E41K) (pI = 6.4) and 5K (3K + D25K, E74K) (pI = 10.2) mutants were tested for cytotoxicity. The 5K mutant was cytotoxic to normal and ...

Combined action of binase and bleomycin toward human lung adenocarcinoma cells

Zelenikhin P.; Makeeva A.; Nguen T.; Siraj Y.; Ilinskaya O. (2016)

Some microbial ribonucleases (RNases) demonstrate selective cytotoxic effect against a wide range of tumor cells. In this context combined use of cytotoxic RNases in complex therapy with other chemotherapeutic agents appears ...

Comparative Analysis of Bacterial Communities Associated with Healthy and Inflamed Peri-implant Tissues

Vankov P.; Ziganshina E.; Ilinskaya O.; Khafizova F.; Khafizov R.; Ziganshin A. (2016)

© 2016, Springer Science+Business Media New York.Dental implants are used to restore dentition defects. However, despite the high efficiency of the method of placing dental implants, their integration can be accompanied ...

Composition of the oil-slime microbial community as determined by analysis of the 16S rRNA gene

Grigoryeva T.; Laikov A.; Rizvanov A.; Ilinskaya O.; Naumova R. (2013)

Analysis of the 16S rRNA genes of the cultured microorganisms of industrial oil-slime revealed predominance (~85-90%) of the Gammaproteobacteria in the community of aerobic heterotrophs and specific oil-slime degraders. ...

Compounds 2,4,6-trinitrotoluene and 2,4-diamino-6-nitrotoluene: The absence of recA-dependent mutagenesis?

Karamova N.; Mynina I.; Garaeva G.; Ivanchenko O.; Ilinskaya O. (1995)

The genotoxicity of 2,4,6-trinitrotoluene (2,4,6-TNT) and its amino derivative, 2,4-diamino-6-nitrotoluene (2,4-DA-6-NT), was studied using the Escherichia coli tester strain PQ37 in the SOS chromotest. The compound ...

Cytotoxic and genotoxic effects of β-(triphenylphosphonio)ethyl carboxylate and of N,N′-bis(dihexylphosphinoylmethyl)-1,4- diaminocyclohexane

Ilinskaya O.; Zelenikhin P.; Kolpakov A.; Karamova N.; Margulis A. (2004)

Background: Several organophosphorous compounds (OPs) are now being tested therapeutically. Cholinesterase inhibition, which in large doses makes these agents effective pesticides, may also be useful in other doses for ...

Browsing by Author "Ilinskaya O."

Browsing by Author "Ilinskaya O."

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