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Browsing by Author "Islamov R."

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Adenoviral vector carrying glial cell-derived neurotrophic factor for direct gene therapy in comparison with human umbilical cord blood cell-mediated therapy of spinal cord injury in rat

Mukhamedshina Y.; Shaymardanova G.; Garanina; Salafutdinov I.; Rizvanov; Islamov R.; Chelyshev Y. (2015)

© 2015 International Spinal Cord Society Study design:Experimental study.Objective:To evaluate the treatment of spinal cord injury with glial cell-derived neurotrophic factor (GDNF) delivered using an adenoviral vector ...
Adenoviral vector carrying glial cell-derived neurotrophic factor for direct gene therapy in comparison with human umbilical cord blood cell-mediated therapy of spinal cord injury in rat

Mukhamedshina Y.; Shaymardanova G.; Garanina; Salafutdinov I.; Rizvanov; Islamov R.; Chelyshev Y. (2016)

© 2016 International Spinal Cord Society.Study design:Experimental study.Objective:To evaluate the treatment of spinal cord injury with glial cell-derived neurotrophic factor (GDNF) delivered using an adenoviral vector ...
Analysis of recombinant VEGF gene expression by genetically modified umbilical cord blood mononuclear cells in experiment in vivo

Mukhamedshina Y.; Solovieva V.; Salafutdinov I.; Cherenkova E.; Fedotova V.; Safiullov Z.; Izmailov A.; Sharifullina G.; Abdulhakov S.; Kaligin M.; Bashirov F.; Muhamediarov M.; Shmarov M.; Naroditskii B.; Kiiasov A.; Rizvanov A.; Islamov R. (2012)

To obtain a significant therapeutic effect transplanted genetically modified cells should have an enhanced ability to survive and active expression of the therapeutic gene. In this paper, by using immunofluorescent staining ...
Analysis of the efficiency of gene-cell therapy in transgenic mice with amyotrophic lateral sclerosis phenotype

Mukhamedyarov M.; Rizvanov A.; Safiullov Z.; Izmailov A.; Sharifullina G.; Solovieva V.; Fedotova V.; Salafutdinov I.; Cherenkova E.; Bashirov F.; Kaligin M.; Abdulkhakov S.; Shmarov M.; Logunov D.; Naroditsky B.; Kiyasov A.; Zefirov A.; Islamov R. (2013)

Amyotrophic lateral sclerosis is a neurodegenerative disease characterized by progressive death of cerebral and spinal motorneurons. Using behavioral tests we studied the efficiency of gene-cell therapy in SOD1 G93A ...
Bioinformatic Analysis of the Sciatic Nerve Transcriptomes of Mice after 30-Day Spaceflight on Board the Bion-M1 Biosatellite

Kuznetsov M.; Rezvyakov P.; Lisyukov A.; Gusev O.; Nikolskiy E.; Islamov R. (2019)

© 2019, Pleiades Publishing, Inc. Abstract: Comparative bioinformatic analysis of sciatic nerve transcriptomes of C57BL/6J mice was carried out. Animals were divided into three groups: Flight, 30-day spaceflight; Recovery, ...
Characterization of spinal cord glial cells in a model of hindlimb unloading in mice

Chelyshev Y.; Muhamedshina Y.; Povysheva T.; Shaymardanova G.; Rizvanov A.; Nigmetzyanova M.; Tiapkina O.; Bondarenko N.; Nikolskiy E.; Islamov R. (2014)

© 2014 IBRO. Exposure to microgravity has been shown to result in damaging alterations to skeletal muscle, bones, and inner organs. In this study, we investigated the effects of microgravity by using a hindlimb unloading ...
Combination of epidural electrical stimulation with ex vivo triple gene therapy for spinal cord injury: A proof of principle study

Fadeev F.; Bashirov F.; Markosyan V.; Izmailov A.; Povysheva T.; Sokolov M.; Kuznetsov M.; Eremeev A.; Salafutdinov I.; Rizvanov A.; Lee H.; Islamov R. (2021)

Despite emerging contemporary biotechnological methods such as gene- and stem cell-based therapy, there are no clinically established therapeutic strategies for neural regeneration after spinal cord injury. Our previous ...
Combined supra-and sub-lesional epidural electrical stimulation for restoration of the motor functions after spinal cord injury in mini pigs

Fadeev F.; Eremeev A.; Bashirov F.; Shevchenko R.; Izmailov A.; Markosyan V.; Sokolov M.; Kalistratova J.; Khalitova A.; Garifulin R.; Islamov R.; Lavrov I. (2020)

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This study evaluates the effect of combined epidural electrical stimulation (EES) applied above (C5) and below (L2) the spinal cord injury (SCI) at T8–9 combined ...
Construction of recombinant adenovirus containing picorna-viral 2A-peptide sequence for the co-expression of neuro-protective growth factors in human umbilical cord blood cells

Garanina E.; Mukhamedshina Y.; Salafutdinov I.; Kiyasov A.; Lima L.; Reis H.; Palotás A.; Islamov R.; Rizvanov A. (2015)

© 2015 International Spinal Cord Society Study design:Experimental study.Objective:Several neuro-degenerative disorders such as Alzheimer’s dementia, Parkinson’s disease and amyotrophic lateral sclerosis (ALS) are associated ...
Construction of recombinant adenovirus containing picorna-viral 2A-peptide sequence for the co-expression of neuro-protective growth factors in human umbilical cord blood cells

Garanina E.; Mukhamedshina Y.; Salafutdinov I.; Kiyasov A.; Lima L.; Reis H.; Palotás A.; Islamov R.; Rizvanov A. (2016)

© 2016 International Spinal Cord Society.Study design:Experimental study.Objective:Several neuro-degenerative disorders such as Alzheimer's dementia, Parkinson's disease and amyotrophic lateral sclerosis (ALS) are associated ...
Epidural stimulation combined with triple gene therapy for spinal cord injury treatment

Islamov R.; Bashirov F.; Fadeev F.; Shevchenko R.; Izmailov A.; Markosyan V.; Sokolov M.; Kuznetsov M.; Davleeva M.; Garifulin R.; Salafutdinov I.; Nurullin L.; Chelyshev Y.; Lavrov I. (2020)

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The translation of new therapies for spinal cord injury to clinical trials can be facilitated with large animal models close in morpho-physiological scale to humans. ...
Evaluation of direct and cell-mediated triple-gene therapy in spinal cord injury in rats

Islamov R.; Izmailov A.; Sokolov M.; Fadeev P.; Bashirov F.; Eremeev A.; Shaymardanova G.; Shmarov M.; Naroditskiy B.; Chelyshev Y.; Lavrov I.; Palotás A. (2017)

© 2017 Elsevier Inc.Current treatment options for spinal cord injury (SCI) are scarce. One of the most promising innovative approaches include gene-therapy, however no single gene has so far been shown to be of clinical ...
Expression of pluripotency transcription factors in human third molar tooth germ derived multipotent mesenchymal stromal cells transfected by plasmid pBud-Sox2-Oct4

Solovyeva V.; Blatt N.; Guseva D.; Yalvac M.; Sahin F.; Islamov R.; Rizvanov A. (2015)

In this study, the double expression cassette plasmid, based on pBudCE4.1 vector encoding transcription factors SOX2 and OCT4 was constructed using standard gene engineering techniques. Expression of recombinant genes was ...
Full-genome study of gene expression in lumbar spinal cord of mice after 30-day space flight on Bion-M1 biosatellite

Islamov R.; Gusev O.; Tanabe A.; Terada M.; Tyapkina O.; Petrov K.; Rizvanov A.; Kozlovskaya I.; Nikolskiy E.; Grigorjev A. (2016)

Experiments were conducted on male mice of the C57BL/6J for full genome study of gene expression. The animals were divided into two groups.The 'flight group' mice that had spent 30 days in space and the 'control group' ...
Gene-modified leucoconcentrate for personalized ex vivo gene therapy in a mini pig model of moderate spinal cord injury

Islamov R.; Bashirov F.; Sokolov M.; Izmailov A.; Fadeev F.; Markosyan V.; Davleeva M.; Zubkova O.; Smarov M.; Logunov D.; Naroditskyi B.; Salafutdinov I.; Rizvanov A.; Turaev R. (2021)

We previously demonstrated that gene-modified umbilical cord blood mononuclear cells overexpressing a combination of recombinant neurotrophic factors are a promising therapeutic approach for cell-mediated gene therapy for ...
Generation of recombinant adenoviral vectors encoding neural cell adhesion molecules ncam1, ncam2 and l1cam

Fedotova V.; Cherenkova E.; Islamov R.; Rizvanov A. (2013)

To succed in gene therapy it is necessary to observe few basic conditions, such as targeted delivery of the therapeutic gene into the target organ and its effective expression. Nowadays targeted delivery of therapeutic ...
Generation of recombinant adenoviruses and lentiviruses expressing angiogenic and neuroprotective factors using Gateway cloning technology

Cherenkova E.; Fedotova V.; Borisov M.; Islamov R.; Rizvanov A. (2012)

The critical aspect in gene and gene-cell therapy is to find an optimal vector - a carrier of genetic information. Viruses represent a natural biological system for gene transfer into eukaryotic cells. One of the most ...
Genetically modified human umbilical cord blood cells expressing vascular endothelial growth factor and fibroblast growth factor 2 differentiate into glial cells after transplantation into amyotrophic lateral sclerosis transgenic mice

Rizvanov A.; Guseva D.; Salafutdinov I.; Kudryashova N.; Bashirov F.; Kiyasov A.; Yalvaç M.; Gazizov I.; Kaligin M.; Sahin F.; Mukhamedyarov M.; Palotás A.; Islamov R. (2011)

Current therapy of a number of neuropsychiatric maladies has only symptomatic modality. Effective treatment of these neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), may benefit from combined ...
Genetically modified human umbilical cord blood mononuclear cells as potential stimulators of neuroregeneration in degenerative disorders of central nervous system

Guseva D.; Rizvanov A.; Kiyasov A.; Islamov R. (2013)

Gene-cell therapy is a new step for the treatment of different human disorders including central nervous system degenerative diseases. In this review we focused on the last challenges in the field of human umbilical cord ...
Human umbilical cord blood cells transfected with VEGF and L1CAM do not differentiate into neurons but transform into vascular endothelial cells and secrete neuro-trophic factors to support neuro-genesis-a novel approach in stem cell therapy

Rizvanov A.; Kiyasov A.; Gaziziov I.; Yilmaz T.; Kaligin M.; Andreeva D.; Shafigullina A.; Guseva D.; Kiselev S.; Matin K.; Palotás A.; Islamov R. (2008)

Genetically modified mono-nuclear cell fraction from human umbilical cord blood (HUCB) expressing human vascular endothelial growth factor (VEGF) and mouse neural L1 cell adhesion molecule (L1CAM) were used for gene-stem ...

Now showing items 1-20 of 43

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Browsing by Author "Islamov R."

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