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Browsing by Author "Egleston B."

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A novel HSP90 inhibitor-drug conjugate to SN38 is highly effective in small cell lung cancer

Gaponova A.; Nikonova A.; Deneka A.; Kopp M.; Kudinov A.; Skobeleva N.; Khazak V.; Ogawa L.; Cai K.; Duncan K.; Duncan J.; Egleston B.; Proia D.; Boumber Y.; Golemis E. (2016)

©2016 AACR.Purpose: Small cell lung cancer (SCLC) is a highly aggressive disease representing 12% to 13% of total lung cancers, with median survival of <2 years. No targeted therapies have proven effective in SCLC. Although ...
Genetic Variants That Predispose to DNA Double-Strand Breaks in Lymphocytes from a Subset of Patients with Familial Colorectal Carcinomas

Arora S.; Yan H.; Cho I.; Fan H.; Luo B.; Gai X.; Bodian D.; Vockley J.; Zhou Y.; Handorf E.; Egleston B.; Andrake M.; Nicolas E.; Serebriiskii I.; Yen T.; Hall M.; Golemis E.; Enders G. (2015)

© 2015 AGA Institute. Background & Aims DNA structural lesions are prevalent in sporadic colorectal cancer. Therefore, we proposed that gene variants that predispose to DNA double-strand breaks (DSBs) would be found in ...
Musashi-2 (MSI2) supports TGF-β signaling and inhibits claudins to promote non-small cell lung cancer (NSCLC) metastasis

Kudinov A.; Deneka A.; Nikonova A.; Beck T.; Ahn Y.; Liu X.; Martinez C.; Schultz F.; Reynolds S.; Yang D.; Cai K.; Yaghmour K.; Baker K.; Egleston B.; Nicolas E.; Chikwem A.; Andrianov G.; Singh S.; Borghaei H.; Serebriiskii I.; Gibbons D.; Kurie J.; Golemis E.; Boumber Y. (2016)

© 2016, National Academy of Sciences. All rights reserved.Non-small cell lung cancer (NSCLC) has a 5-y survival rate of ∼16%, with most deaths associated with uncontrolled metastasis. We screened for stem cell identity-related ...
Opposing effects of inhibitors of Aurora-A and EGFR in autosomal-dominant polycystic kidney disease

Nikonova A.; Deneka A.; Eckman L.; Kopp M.; Hensley H.; Egleston B.; Golemis E. (2015)

© 2015 Nikonova, Deneka, Eckman, Kopp, Hensley, Egleston and Golemis. Aurora-A kinase (AURKA) overexpression in numerous tumors induces aneuploidy, in part because of cytokinetic defects. Alisertib and other small-molecule ...
Systematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancer

Nicolas E.; Arora S.; Zhou Y.; Serebriiskii I.; Andrake M.; Handorf E.; Bodian D.; Vockley J.; Dunbrack R.; Ross E.; Egleston B.; Hall M.; Golemis E.; Giri V.; Daly M. (2015)

Risk assessment for prostate cancer is challenging due to its genetic heterogeneity. In this study, our goal was to develop an operational framework to select and evaluate gene variants that may contribute to familial ...

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Browsing by Author "Egleston B."

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