© 2020, Human Stem Cell Institute. All rights reserved. Tay-Sachs disease (OMIM 272800) belongs to the group of autosomal-recessive disorders, caused by β-hexosaminidase A (HexA) enzyme deficiency, resulting in GM2-ganglioside ...

Searching for new effective and low-toxic antiphlogistics among the new classes of compounds that could have a selective and prolonged effect and minimum side effects is highly relevant. In this respect, the promising ...

© Schattauer 2014. Thrombin is essential for blood coagulation but functions also as a mediator of cellular signalling. Gene expression microarray experiments in human monocytes revealed thrombin-induced upregulation of a ...

© 2019 Elsevier B.V. Backgound and aims: The low-density lipoprotein receptor-deficient (Ldlr−/−) mouse has been utilized by cardiovascular researchers for more than two decades to study atherosclerosis. However, there has ...